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cancer cell line

cell line established from a tumor tissue; the most widely used reagent in laboratory-based cancer research to study the biology of cancer and to test cancer treatments

controlled vocabulary

a standardized terminology for use in indexing and retrieval of information


embryonic stem cells (ES cells or ESCs)

pluripotent stem cells generated from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo; ESCs are being studied to be used as clinical therapies, models of genetic disorders, and cellular/DNA repair


finite cell line

cell line that can undergo a finite number of divisions



hybrid cell line that results from the fusion of B cells and myeloma cells; hybridomas are immortalized cells which produce antibodies


immortalized cell line

cell line that can divide indefinitely

induced pluripotent stem cells (iPSCs)

cells derived from skin or blood cells that have been reprogrammed back into an embryonic-like pluripotent state, thus enabling the development of an unlimited source of any type of human cell needed for therapeutic purposes


pluripotent cell

cell capable of giving rise to several different cell types

primary cells

cells taken directly from the tissue and processed to establish them under optimized culture for a limited number of divisions; they most closely represent the tissue of origin conditions


short tandem repeat (STR)

short sequences of DNA (2–6 bp) that are repeated numerous times in a head-tail manner; the number of repeat units is highly variable among individuals, hence STRs are used for identification and authentication purposes

stem cells

cells from which all other cells with specialized functions are generated


transformed cells

normal cells which have been modified so as to become immortal

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