Glossary


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C

cancer cell line

cell line established from a tumor tissue; the most widely used reagent in laboratory-based cancer research to study the biology of cancer and to test cancer treatments


controlled vocabulary

a standardized terminology for use in indexing and retrieval of information


E

embryonic stem cells (ES cells or ESCs)

pluripotent stem cells generated from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo; ESCs are being studied to be used as clinical therapies, models of genetic disorders, and cellular/DNA repair


F

finite cell line

cell line that can undergo a finite number of divisions


H

hybridoma

hybrid cell line that results from the fusion of B cells and myeloma cells; hybridomas are immortalized cells which produce antibodies


I

immortalized cell line

cell line that can divide indefinitely


induced pluripotent stem cells (iPSCs)

cells derived from skin or blood cells that have been reprogrammed back into an embryonic-like pluripotent state, thus enabling the development of an unlimited source of any type of human cell needed for therapeutic purposes


P

pluripotent cell

cell capable of giving rise to several different cell types


primary cells

cells taken directly from the tissue and processed to establish them under optimized culture for a limited number of divisions; they most closely represent the tissue of origin conditions


S

short tandem repeat (STR)

short sequences of DNA (2–6 bp) that are repeated numerous times in a head-tail manner; the number of repeat units is highly variable among individuals, hence STRs are used for identification and authentication purposes



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