Section outline

  • DNA methylation and methylome analysis with NGS

    Fribourg, 10-11 February 2015

    Overview

    Methylations of the DNA are important modifications that affect the DNA of bacteria and higher eucaryotes. The DNA can be modified on different bases (6mA, 4mC, 5mC) and these modifications have various effects, e.g., on gene expression or protection against foreign DNA. These modifications can be transmitted from generation to generation, they are called epigenetics modifications. Current next generation sequencing technologies allow for the detection of those modifications at the genome level introducing the « methylome ». In addition Histone modifications are also part of the epigenomics modifications that can influence gene expression. These modification can be analyzed by NGS methods. In this workshop we will study the methods used to produce and to analyze this NGS data.

    Objectives

    Learn about DNA methylation and other chromatin modifications.

    Learn the tools and databases available to study the methylome.

    Requirements

    Requirements: a portable computer with WIFI and 4Gb RAM. Basic knowledge of the R package.

    Application

    Application on the StarOmics page. 

    Deadline for registration and cancellation is set to Jan 31, 2015.

    Location

    Additional information

    The course will be taught by Philipp Bucher, Christoph Schmid and Michael Stadler.

    For administrative questions, please contact staromics@cuso.ch
    For technical and scientific questions, please contact laurent.falquet@unifr.ch