Proteomics, and in particular the use of Mass Spectrometry in Proteomics, does generate large amounts of data. These data are used to derive biologically relevant knowledge. Journals and founders are recommending, if not requesting, that data supporting results are submitted to dedicated repositories such as PRIDE and PASSEL. A portion of these data is used to populate knowledgebases such as UniProtKB and NeXtProt. Mechanisms such as proteomeXchange exist that help scientists with data deposition, data query and data recovery.