Introduction to 3D-Structure Visualization and Homology Modeling using the Swiss-Model Workspace
Lorenza Bordoli, SIB & Biozentrum University Basel
Three-dimensional protein structures are key to a detailed understanding of the molecular basis of protein function. Combining sequence information with 3D structure gives insights for the development of effective rational strategies for experiments such as site directed mutagenesis, studies of disease related mutations, or the structure based design of specific inhibitors.
The goal of this course is to expose the participants to 3-dimensional structures of proteins. Analysis and visualization softwares (DeepView) will be used to display, analyze, compare and interpret protein structures. The second part of the course is dedicated to protein structure prediction using the Swiss-Model expert system for homology modeling.